Speckle tracking technology can be used for early identification of the impairment of left ventricular geometric structure and systolic dysfunction in elderly hypertensive patients with obesity
LI Ping
YANG Hongyu
ZHOU Linyan
KANG Chunsong
Abstract：Objective To investigate the impact of obesity on left ventricular geometry and myocardial mechanics in elderly hypertensive patients using speckle tracking combined with conventional echocardiography.Methods We enrolled 152 elderly patients with primary hypertension from Shanxi Bethune Hospital between January and December 2023.Participants were categorized based on their BMI into normal weight group(n=62),overweight group(n=50),and obesity group(n=40),with an additional 50 healthy controls.Echocardiography was performed to assess conventional and global longitudinal strain(GLS)parameters.We analyzed the differences in echocardiographic parameters and the prevalence of left ventricular geometric configurations across the groups.Results GLS progressively decreased from control group to normal weight group,overweight group and obese group.Left ventricular mass index(LVMI)gradually increased from control group,normal weight group,overweight group and obese group(P<0.05).The prevalence of eccentric hypertrophy was higher in overweight and obesity groups compared to the control and normal weight groups;The prevalence of concentric hypertrophy increased gradually from the control group to the normal weight group,overweight group and obese group(all P<0.05).Correlation analysis revealed that GLS was negatively correlated with age,systolic blood pressure(SBP),BMI and duration of hypertension;LVMI was positively correlated with age,SBP and BMI(P<0.05).Multi-factor linear regression analysis identified that SBP and BMI are the factors of GLS;BMI is an independent risk factor for elevated LVMI.Conclusion Obesity exerts a synergistic effect on left ventricular systolic and diastolic dysfunction and left ventricular hypertrophy in hypertensive patients.BMI is an independent risk factor for left ventricular systolic dysfunction and left ventricular hypertrophy,with the obese condition being more likely to induce left ventricular hypertrophy,which with increased cardiovascular risk and poorer prognosis.Early detection and intervention of altered left ventricular geometry in these patients can aid in reducing the occurrence of cardiovascular diseases among hypertensive and obese individuals.
Keywords：hypertensionobesityleft ventricular mass indexgeometric configurationmyocardial mechanics
Publication Date：2025-01-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 37-43 )