Neuroimaging study of brain structural and functional abnormalities in patients with Parkinson's disease with sleep disorders
ALIYE·Abulizi
AN Peng
WANG Puqing
GAO Ping
Abstract：In the field of Parkinson's disease(PD),sleep disorders are recognized as one of the most common non-motor symptoms,closely related to the development of motor and non-motor symptoms of the disease.Research shows that patients with PD and sleep disorders(such as rapid eye movement sleep behavior disorder)progress faster than those without sleep disorders,and most sleep disorder patients will eventually progress to Parkinson's disease.At present,the relationship between sleep disorders and the pathogenesis of PD has not been fully clarified.Therefore,early detection of abnormal structural and functional changes in patients with PD and sleep disorders is of great value in delaying disease progression and preventing the transformation of sleep disorders into PD.In recent years,with the continuous development of imaging technology and its wide application,many neuroimaging techniques have been widely used in the study of PD patients with non-motor symptoms,such as diffusion tensor imaging,resting-state functional-MRI,neuromelanin sensitive-MRI,SPECT/PET and Transcranial sonography.They play a key role in the study of Parkinson's disease,and they have important value in the early diagnosis,monitoring and clarifying the pathogenesis of the disease.This article reviews the imaging research progress of the above neuroimaging techniques in patients with Parkinson's disease and sleep disorders.To better understand the pathophysiological mechanisms of PD accompanied by sleep disorders,and to guide clinical diagnosis and treatment.
Keywords：Parkinson's diseaserapid eye movement sleep behavior disorderrestless legs syndromeneuroimaging technology
Publication Date：2024-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1271-1276 )