The potential value of metabolic glutamate receptor 5 PET imaging in the diagnosis and treatment monitoring of depression
TIAN Qingwen
ZHAI Luoping
MA Le
LIU Ye
ZHANG Wanchun
Abstract：Depression is a common mental disorder,but its pathogenesis is intricate and there is still only a partial understanding of its underlying pathophysiology.Studies have shown that metabolic glutamate receptor 5(mGluR5)plays a key role in the pathophysiology of depression.Depression animal model studies and in vitro radiotracer autoradiography have provided insights into the changes of mGluR5 in depression,but limitations in its translation to the clinic have restricted further understanding of depression.With the continued development of PET and radiotracers,nuclide noninvasive receptor imaging has made it possible to study the availability of mGluR5 for depression in vivo.This review summarised the development of the mGluR5 PET radioligand,provided the results of clinical and preclinical PET in vivo studies supporting the involvement of mGluR5 in the pathophysiological processes of depression,and discussed the potential value of mGluR5 PET imaging in depression.
Keywords：depressionmGluR5ketaminePETradioligand
Publication Date：2024-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1260-1265 )