18 F-FDG PET/CT metabolic parameters and serum tumor markers help reflect some clinicopathological features of gastric cancer
JIANG Yuming
SONG Liping
Abstract：Objective To investigate the correlation between 18F-FDG PET/CT metabolic parameters,serum tumor markers and clinicopathological characteristics of patients with gastric cancer.Methods The 18F-FDG PET/CT imaging data and clinical data of 41 patients with pathologically confirmed gastric cancer who underwent 18F-FDG PET/CT in the Department of Nuclear Medicine of our hospital from January 2019 to September 2023 were retrospectively analyzed.Standardized uptake value(SUV)max,SUVpeak,SUVmean,maximum standard intake value for fat removal(SUL),tumor metabolic volume(MTV)and total glycolysis(TLG)of primary gastric cancer were measured,and the expression levels of serum tumor markers were recorded.The differences of metabolic parameters and tumor markers among different clinical stages,tumor tissue differentiation and Lauren classification groups were compared,and the correlation between metabolic parameters,tumor markers and clinicopathological characteristics was analyzed.Results There were significant differences in SUVmax,SUVpeak,SUVmean,SUL,TLG,MTV,and the positive detection values of carcinoembryonic antigen(CEA),carbohydrate antigen(CA)19-9 and CA72-4 in different clinical stages(P<0.05).There was a significant difference in MTV among different tumor differentiation(P<0.05),while there was no significant difference in SUVmax,SUVpeak,SUVmean,SUL,TLG and the positive detection values of CEA,CA19-9 and CA72-4(P>0.05).There was no significant difference in each index between different Lauren types(P>0.05).The accuracy of SUVmax,SUVpeak,SUVmean,SUL,TLG,MTV combined with CEA,CA19-9,CA72-4 in predicting clinical stage reached 92.7%.Conclusion 18F-FDG PET/CT metabolic parameters combined with serum tumor markers can help to reflect some of the clinicopathological characteristics of tumors,which is of great significance for the development of clinical individualized treatment plan.
Keywords：18F-FDG PET/CTgastric cancertumor markersmaximum standardized uptake value
Publication Date：2024-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1237-1242 )