Age-related differences in the association between sleep disorder characteristics and thalamic subregion volumes in patients with insomnia:based on MRI
PAN Xingduo
WANG Yajun
LI Ming
LI Yanyan
ZHOU Xiaoyan
ZHANG Zhen
LIU Chuanhao
WU Yin
LIN Zengru
Abstract：Objective To observe the performance of sleep disorders in insomnia patients of different ages,and to compare the volume differences of thalamic subregions in insomnia patients of all ages based on MRI acquisition of nuclear magnetic data of the brain,and to explore the correlation between sleep disorders and the volume of thalamic subregions.Methods Sixty patients with primary insomnia who attended the Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine from July 2023 to June 2024 were categorized by age into young group(18-44 years old),middle-aged group(45-59 years old),and old-aged group(60-75 years old),20 cases per group.The Pittsburgh sleep quality index was used to assess the sleep quality and degree of insomnia of the patients in each group,and the Siemens 3.0T Prisma magnetic imaging system was used to collect 3D T1 structural image data of the patients,to automatically segment and measure the volumes of the thalamus and six subregions,and to analyze and compare the thalamic subregions of the patients in each group.We analyzed and compared the volume differences of the thalamic subregions in each group of patients,and explored the correlation between the patients'sleep disorders and the volume of the thalamic subregions using partial correlation analysis.Results The Pittsburgh sleep quality index total score,sleep latency,habitual sleep efficiency and insomnia degree grading differed among patients with primary insomnia of different ages(P<0.05),and significant intergroup differences existed among the medial thalamus,lateral thalamus,posterior thalamus and thalamus total volume(P<0.05).Moreover,the results of the partial correlation analysis showed that the sleep efficiency was negatively correlated to the volume of posterior thalamus(r=-0.274,P=0.038).Conclusion Primary insomnia patients of different age groups have different manifestations of sleep disorders.MRI was used to collect brain nuclear magnetic data from insomnia patients,and the analysis of the MRI data revealed that it might be related to the atrophy of grey matter structures in some brain regions of the thalamic system,which provides an important reference for individualized treatment of the patients and improvement of clinical prognosis.
Keywords：insomniasleep disorderthalamic subregionagestructural MRI
Publication Date：2024-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1183-1188 )