1.5T magnetic resonance imaging can effectively moniter the dynamic changes of cerebral lesions in different stages of ischemic stroke in SD rats
LI Xueqi
YAKUFU Suobinuer
TANG Bin
HU Xinqi
SHAO Hua
JIANG Lei
Abstract：Objective To assess the feasibility and imaging characteristics of clinical 1.5T MRI in visualizing cerebral lesions at different time points(6 h,3 d,5 d,7 d,14 d)in an acute ischemic stroke rat model.Methods Ten healthy male Sprague-Dawley rats,aged 10-12 weeks,were randomly selected and subjected to permanent middle cerebral artery occlusion via the filament method to induce ischemic stroke.MRI scans,including T1WI,T2WI,T2 FLAIR,and DWI,were conducted using a 1.5T clinical MRI scanner at the specified time intervals(6 h,3 d,5 d,7 d,14 d),capturing morphological and signal intensity changes across infarction stages in the rats.Results The DWI sequence obtained from the 1.5T MRI scanner facilitated diagnosis of ultra-acute cerebral infarction in rats,effectively delineating infarction extent and scope.Infarct lesions in the model rats exhibited distinct imaging changes across stages,with signal intensity and morphology alterations becoming apparent in conventional MRI sequences as the infarction progressed.Conclusion The clinical 1.5T MRI technique proves effective in monitoring time-dependent dynamic changes in cerebral lesions in the ischemic stroke rat model.DWI,in particular,exhibits outstanding diagnostic capacity in ultra-acute infarction,thus providing valuable imaging support for advanced clinical research and therapeutic planning.
Keywords：ischemic strokeclinical medical magnetic resonance imagingrat model of middle cerebral artery occlusiondiffusion weighted imaging
Publication Date：2024-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 1163-1169 )