Advances in molecular imaging of targeted hepatic stellate cells for the assessment of liver fibrosis
LI Hanmei
YU Jinhong
JIANG Qiong
FENG Linli
ZHANG Juying
YANG You
Abstract：Liver fibrosis is a degenerative condition of the liver induced by a number of chronic liver disorders that is distinguished by aberrant deposition of hepatic extracellular matrix.Liver fibrosis is reversible in its early stages,thus early detection and proper staging are critical in clinical practice.Hepatic stellate cells,which are the core cells in the formation of hepatic fibrosis,play an important role in its initiation and progression.Molecular imaging approaches for targeting hepatic stellate cells integrate physiological and pathological metabolic molecular information in an accurate and non-invasive manner,allowing for the early and specific identification of liver fibrosis.As a result,the advancement of targeted hepatic stellate cell molecular imaging in the assessment of liver fibrosis serves an important purpose and significance,not only in improving diagnostic accuracy and therapeutic efficacy of liver fibrosis,but also in promoting the development and innovation of related disciplines.In this paper,we will review recent research progress in molecular imaging of targeted hepatic stellate cells in liver fibrosis,as well as summarize the research and application value of different molecular probes against various hepatic stellate cell targets for the diagnosis and staging of early liver fibrosis.
Keywords：targetinghepatic stellate cellsliver fibrosisbiomarkersmolecular imaging
Publication Date：2024-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1012-1016 )