Whole-body bone scintigraphy and SPECT/CT imaging analysis of SAPHO syndrome
CUI Can
LI Junqiu
YU Meiyan
WEN Qingxiang
Abstract：Objective To analyze the imaging characteristics of whole-body bone scintigraphy and SPECT/CT in SAPHO syndrome and to investigate the diagnostic value of the two examination methods in SAPHO syndrome.Methods The clinical,whole-body bone scintigraphy,and SPECT/CT data of 41 patients with SAPHO syndrome admitted to Beijing Hospital of Traditional Chinese Medicine,Capital Medical University from January 2017 to December 2022 were retrospectively analyzed.Results Among the 41 patients,56%had a combination of skin lesions,and the proportions of patients with elevated ESR,CPR,C3 complement,and C4 complement were 63%,59%,17%,and 6%,respectively,while 14%were HLA-B27 positive.The whole-body bone scintigraphy showed that there were 6 cases of anterior chest wall involvement,1 case of thoracic vertebra involvement,1 case of thoracolumbar and bilateral sacroiliac joint involvement,and the remaining 33 cases of multisite involvement,in the order of the anterior chest wall(95%),spine(58%),sacroiliac joints(46%),joints of the limbs(22%),ribs(12%),pubis(7%),ischium(5%),femur and skull(2%each).Nineteen cases underwent SPECT/CT tomography of the chest and lumbosacral.The anterior chest wall lesions were mainly located in the sternoclavicular joints and the first sternocostal joints,and the"bullhead sign"was a characteristic manifestation of the disease.The spinal lesions were mostly distributed in the thoracolumbar spine,and the osteosclerosis of the anterior corners of the vertebral body was more specific.Sacroiliac joints were mostly involved bilaterally and on the surface of the ilium and mostly showed osteophytic sclerosis.Conclusion Whole-body bone scintigraphy can comprehensively evaluate the whole-body bone and joint involvement.SPECT/CT combines the metabolic information of bone tomography and the anatomical information of CT at the same time.The combination of the two is of great value in the early diagnosis,accurate localization,and disease assessment of SAPHO syndrome.
Keywords：SAPHO syndromeradionuclide imagingbone scintigraphySPECT/CT
Publication Date：2024-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 941-945 )