Non-linear relationship between interatrial septum thickening rate and the risk of stroke in patients with atrial fibrillation:based on inverse probability weighting
HONG Junrong
HUANG Yan
WU Tianchen
JIANG Shushu
LIANG Yan
Abstract：Objective To investigate the relationship between interatrial septum thickening rate and the risk of stroke in patients with atrial fibrillation using inverse probability weighting(IPTW).Methods A total of 265 patients with atrial fibrillation were admitted to Nanjing Hospital of Chinese Medicine from January 1,2020 to June 30,2023,were enrolled in this study.The interatrial septum thickening rate was divided into three groups based on tertiles:group 1(0.01-0.089),group 2(0.089-0.317),group 3(0.317-0.69).IPTW was used to adjust for confounding factors and balance group differences.The weighted restricted cubic spline curve was used to explore the relationship between interatrial septum thickening rate and the risk of stroke in patients with atrial fibrillation.Results IPTW analysis showed that the risk of stroke in patients with atrial fibrillation in group 2 was not significantly different from that in group 1(P=0.584).However,the risk in group 3 was reduced by 86%compared to group 1(OR=0.144,95%CI:0.055-0.380,P<0.001).Restricted cubic spline curve analysis,based on a developed weighting equation,indicated that the cut-off value for interatrial septum thickening rate was 0.321.There was a decreasing trend in the risk of stroke among patients with atrial fibrillation whose interatrial septum thickening rate was greater than 0.321.Conclusion There was a non-linear relationship between interatrial septum thickening rate and the risk of stroke in patients with atrial fibrillation.
Keywords：atrial fibrillationcerebral infarctionatrial septal thickening rateinverse probability weighting method
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 830-835 )