Progress in the mechanism of photodynamic therapy in the diagnosis and treatment of cholangiocarcinoma
QI Shuo
CHEN Kang
ZHOU Lei
LIU Changjun
TIAN Binzhang
PENG Chuang
CHENG Wei
Abstract：Cholangiocarcinoma is a rare but dangerous tumor with low early diagnosis rate and poor prognosis. Surgical resection is an effective method for radical treatment of cholangiocarcinoma, but the postoperative recurrence rate is high. However, the curative effect of radiotherapy, chemotherapy and interventional therapy is not yet satisfactory. Photodynamic therapy, utilizes photosensitizers and laser for tumor treatment, has achieved initial results in the application of cholangiocarcinoma, but further research is needed on the mechanism of photodynamic therapy on cancer cells. This article reviewed the mechanism of photodynamic therapy in the treatment of cholangiocarcinoma and discusses the mechanisms of immunotherapy, angiogenesis inhibition, antioxidants and heat shock proteins. Subsequently, the combined effects of photodynamic therapy combined with targeted drugs/radiation therapy was explored to provide theoretical basis for clinical treatment of cholangiocarcinoma, aiming to provide safe and effective therapeutic measures for cholangiocarcinoma in clinical practice.
Keywords：photodynamic therapycholangiocarcinomadiagnosismechanism of actionprogress
Publication Date：2024-06-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 661-664 )