The correlation of depression with imaging markers and cognitive function in patients with hypertensive-cerebral small vessel disease
CAO Jiali
HAN Yongchang
ZHANG Yue
LI Fan
LI Shengnian
SHEN Mengmeng
YAO Haoyue
ZHANG Xianhu
LIU Chong
Abstract：Objective To explore the relationship between depression and imaging markers as well as total burden in patients with hypertensive-cerebral small vessel disease (HT-CSVD), and analyze the correlation between depression and cognitive function. Methods A total of 141 patients with HT-CSVD admitted to Baoding No.1 Central Hospital from May to December 2023 were divided into depression group (n=49) and non-depression group (n=92) based on the Hamilton depression scale. Demographic information, past medical history, MRI images, laboratory tests and cognitive function scores were collected to analyze the risk factors of depression and the relationship between depression and cognitive function in HT-CSVD patients. Results Lacune, basal ganglia enlarged perivascular space (BG-EPVS), and the total burden of CSVD imaging of the patients in the depression group was higher than that of the non-depression group, and albumin levels were lower in the depression group , and the difference was statistically significant (P<0.05). Multifactorial Logistic regression analysis showed that lacune and BG-EPVS were independent risk factors for depression in HT-CSVD patients. The results of the analysis of the relationship between depression and cognitive function in HT-CSVD patients revealed that the total MoCA score and the individual scores of the cognitive domains such as visual-spatial and executive functions, naming, attention, language, delayed recall, and orientation were lower in the depression group compared to the non-depression group, with statistically significant differences (P<0.05). Spearman's correlation analyses showed a negative correlation between depression scores and MoCA scores, as well as visual-spatial and executive functions, naming, attention, language, delayed recall and orientation (P<0.05). Conclusion Lacune and BG-EPVS are independent risk factors for depression in HT-CSVD patients. Depression in HT-CSVD patients is closely related to cognitive function. Depression in HT-CSVD patients is associated with decreased overall cognitive function, visual space and executive function, naming, attention, language, delayed recall and orientation.
Keywords：cerebral small vessel diseasehypertensiondepressionimaging markerscognitive function
Publication Date：2024-06-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 638-643 )