FAPI imaging:breaking the limitations of traditional PET/CT in cancer diagnosis
DONG Xin
SUN Yao
WANG Fei
ZHANG Shu
XIE Guozhu
Abstract：In recent years,traditional 18F-FDG PET/CT has been widely used in cancer diagnosis.However,it has certain limitations in detecting small metastases and lymph node metastases,as well as imaging specificity.Fibroblast activation protein-α(FAPα)is overexpressed on cancer-associated fibroblasts in approximately 90%of malignant solid tumors.68Ga-labelled radiopharmaceuticals-FAP-inhibitors(FAPI)-have been developed for PET by targeting FAPα,and showed breakthrough diagnostic potential in various tumors.This article reviews the molecular basis and development history of FAPI imaging technology,and reviews the current clinical application status of FAPI imaging in various cancers such as breast cancer,lung cancer,and pancreatic cancer,showing its diagnostic efficacy compared to traditional 18F-FDG.Finally,it discusses the main challenges FAPI imaging faces in current clinical promotion,aiming to highlight the great potential of FAPI imaging in cancer diagnosis and its future research directions,to promote further improvement of the technology and its widespread application in clinical practice.
Keywords：FAPIPET-CTradiopharmaceuticalscancer diagnosis
Publication Date：2024-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 542-547 )