Evaluating glymphatic system function and relationship with insulin resistance in newly diagnosed type 2 diabetes mellitus patients by diffusion tensor image analysis along the perivascular space
YIN Rendi
WANG Nan
ZHANG Chao
YING Changjiang
Abstract：Objective To evaluate the glymphatic system function in patients with newly diagnosed type 2 diabetes mellitus(T2DM)by using diffusion tensor image analysis along the perivascular space(DTI-ALPS),and to explore the relationship with insulin resistance of homeostasis model(HOMA-IR).Methods A total of 30 patients with newly diagnosed T2DM,clinically diagnosed at the Affiliated Hospital of Xuzhou Medical University from April to June 2023,were selected as the newly diagnosed T2DM group.Additionally,30 healthy individuals who underwent physical examinations at the hospital and were matched with the newly diagnosed T2DM group in terms of age and gender were selected as the control group.The clinical indicators of the subjects were collected,including glycosylated hemoglobin(HbA1c)(%),fasting blood glucose(mmol/L),and fasting insulin(pmol/L)levels.The homeostasis model assessment(HOMA-IR)index of insulin resistance was calculated.Sixty subjects were scanned by a 3.0T MRI,and the ALPS index was calculated to compare the differences between the two groups.Pearson correlation was used to analyze the correlation between HOMA-IR and ALPS index in the newly diagnosed T2DM group.Results Significant differences were observed in fasting plasma glucose,fasting insulin,glycosylated hemoglobin,and HOMA-IR between the two groups(P<0.05).The ALPS index was significantly decreased in the newly diagnosed T2DM group(1.50±0.22 vs 1.31±0.18,P<0.001)and was negatively correlated with HOMA-IR(r=-0.622,P<0.001).Conclusion The DTI-ALPS index can be used to evaluate the glymphatic system function in patients with newly diagnosed T2DM,and the decline in glymphatic system function is related to insulin resistance.
Keywords：type 2 diabetes mellitusdiffusion tensor image analysis along the perivascular spaceinsulin resistanceglymphatic system
Publication Date：2024-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 513-517 )