Relationship between ultrasonography and contrast-enhanced ultrasonography and B7-H4 in breast invasive ductal carcinom
ZHANG Jingyue
HOU Xueqin
YAN Ruiqian
LIU Yibin
LI Zhimin
GAO Junxi
Abstract：Objective To analyze the relationship and correlation between ultrasonography and contrast-enhanced ultrasound features and the expression of B7-H4 in invasive ductal carcinoma(IDC).Methods A total of 136 female patients admitted to the Department of Breast Surgery,First Affiliated Hospital of Xinjiang Medical University from January 2015 to January 2021 were retrospectively analyzed.Following surgical resection,specimens were histopathologically confirmed as IDC.Immunohistochemistry was utilized to detect the expression of B7-H4 in the cell membrane and cytoplasm of breast cancer cells from the pathological specimens.Prior to surgery,all patients underwent two-dimensional ultrasound and contrast-enhanced ultrasound of the breast.Ultrasound and contrast-enhanced ultrasound characteristics of the lesions were documented,and their correlation with the expression level of B7-H4 in IDC was subsequently analyzed.Results The expression of B7-H4 in the cell membrane and cytoplasm of breast cancer cells was detected by immunohistochemistry in 136 patients.Due to the high temperature during antigen repair or other reasons,2 pieces of tissue were removed.Among the remaining 134 sections,6 were negative expression and 128 were positive expression,including 85 high expression and 43 low expression.In different B7-H4 expression groups,when B7-H4 was highly expressed,the two-dimensional ultrasound of IDC mass was prone to characteristics such as aspect ratio>1,irregular shape,interruption of surrounding tissue echo,posterior echo attenuation,lymph node metastasis(P<0.05);The characteristics of IDC contrast-enhanced ultrasound were prone to the characteristics of internal filling defect and peripheral convergence sign after enhancement(P<0.05).The high expression of B7-H4 was positively correlated with the two-dimensional ultrasound features such as tumor morphology,aspect ratio,posterior acoustic attenuation and surrounding tissue echo in two-dimensional IDC ultrasound(r=0.188,0.240,0.185,0.344,P<0.05).Conclusion IDC ultrasound and contrast-enhanced ultrasound findings have a certain correlation with the expression of B7-H4.The characteristics of IDC ultrasound and contrast-enhanced ultrasound can predict the expression of molecular marker B7-H4 in IDC,and then provide a reliable imaging reference for the evaluation of the possible B7-H4 targeted therapy effect of breast cancer.
Keywords：invasive ductal carcinomaB7-H4ultrasonographycontrast-enhanced ultrasound
Publication Date：2024-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 496-501 )