Correlation between dynamic contrast-enhanced magnetic resonance imaging and diffusion weighted imaging parameters and tumor mutation burdenin breast cancer
ZHANG Chongjie
YANG Juehong
WANG Junbo
HAO Xiaoning
Abstract：Objective To explore the correlation between dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)and diffusion weighted imaging(DWI)parameters and tumor mutation burden(TMB)in breast cancer,and to evaluate the potential value of DCE-MRI and DWI in breast cancer immunotherapy.Methods The clinical data and preoperative MRI examination results of 100 patients with breast cancer from 2019 to 2021 were retrospectively analyzed,and the imaging features of DCE-MRI and DWI were extracted.According to the median TMB value(5.4/Mb),100 patients were divided into high TMB expression group(TMB≥5.4/Mb,n=28)and low TMB expression group(TMB<5.4/Mb,n=72).The image features from DCE-MRI and DWI were collected,and the apparent diffusion coefficient(ADC)and dynamic enhancement curve type were calculated.High-throughput sequencing technology was used to detect gene mutations in tumor tissues,and TMB values were calculated.The correlation between DCE-MRI and DWI parameters and TMB values,as well as the relationship with breast cancer pathological indicators(ER,PR,HER-2,Ki67)were analyzed.Univariate and multivariate Logistic regression analyses were used to screen the independent risk factors affecting TMB values.Results Among the DCE-MRI and DWI parameters,ADC value,dynamic enhancement curve type,peak signal intensity,time-signal intensity curve slope were significantly negatively correlated with TMB value(P<0.05),while peak time,time-signal intensity curve area were significantly positively correlated with TMB value(P<0.05).Among the breast cancer pathological indicators,ER,PR,HER-2 and Ki67 expression were not significantly correlated with TMB value(P>0.05).Multivariate Logistic regression analysis showed that ADC value,dynamic enhancement curve type and peak time were independent risk factors affecting TMB value.Conclusion DCE-MRI and DWI parameters are significantly correlated with TMB value in breast cancer,they can be used as an auxiliary means to evaluate the effect of breast cancer immunotherapy.
Keywords：breast cancermagnetic resonance imagingdynamic enhancementdiffusion weightedtumor mutation burden
Publication Date：2024-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 414-419 )