Application value of quantitative CT in evaluating type 2 diabetes mellitus complicated with interstitial lung abnormalities
ZHANG Li
FAN Qiuju
DANG Shan
HAN Dong
ZHANG Min
YU Nan
Abstract：Objective To explore the sensitive imaging indicators of effective recognition of type 2 diabetes mellitus(T2DM)complicated with interstitial lung abnormalities by quantitative CT,aim at contributing to the early diagnosis of T2DM complicated with interstitial lung disease and effectively delaying the progression of diabetic lung damage.Methods Seventy patients with clinically diagnosed T2DM with interstitial lung abnormalities detected on chest CT from January 2022 to August 2023 at the Affiliated Hospital of Shaanxi University of Chinese Medicine were retrospectively collected,and 62 non-diabetic physical examination screeners without abnormal changes on chest CT were also collected.The chest CT images were postprocessed by Dexin-FACT"digital lung"software,and the quantitative parameters of CT were obtained,including whole lung volume,emphysema index(LAA-950%),pulmonary fibrosis evaluation index(LAA-700～-200%),pulmonary small vessel index(the ratio of lumen area to number of blood vessels around the bronchus with a diameter of 2mm in the lower lobe of the lung,TAV/TNV).The differences of quantitative CT parameters between the two groups were compared and the indexes with statistical significance were analyzed by ROC curve.Results the LAA-700--200%in the T2DM group was significantly higher than that in the control group(Z=-4.229,P<0.001),while the LAA-950%and TAV/TNV in the T2DM group were significantly lower than those in the control group(Z=-2.173,P<0.05;t=-3.904,P<0.001),but there was no significant difference in whole lung volume between the two groups(P>0.05).LAA-700--200%had the highest diagnostic efficiency in distinguishing T2DM complicated with interstitial lung abnormalities,with an AUC of 0.71.Conclusion The quantitative parameters of lung CT in patients with T2DM complicated with interstitial lung abnormalities are different from those in the control group,and small blood vessel injury in the lung may be a key target organ for lung injury in T2DM patients.
Keywords：diabetes mellitusinterstitial lung abnormalitiesquantitative analysislung damageCT
Publication Date：2024-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 177-182 )