Diagnostic value of multi-modality spectral CT imaging based on iodine maps in papillary thyroid carcinoma
LIU Jingyao
FAN Wenping
LIU Mengqi
GE Wenhao
YAO Hui
LIU Mingbo
CHEN Zhiye
Abstract：Objective To evaluate the diagnostic value of spectral CT with quantitative enhancement parameters in the papillary thyroid carcinoma(PTC).Methods Fifty cases with PTC were retrospectively studied by analyzing spectrum base image at the Hainan Hospital of PLA General Hospital from May 2019 to January 2023,which would generate arterial enhancement fraction(AEF)and extracellular volume fraction(ECV)images.The AEF and ECV value were measured in the lesion and normal thyroid tissue on the same level.Mann-Whitney U test was used for the group comparison,and ROC curve was used to evaluate the diagnostic efficacy of AEF and ECV with Z test for the area under the curve.Results The AEF and ECV value of PTC were significantly lower than that of normal thyroid tissue(UAEF=1311.00,PAEF=0.02;UECV=394.50,PECV<0.0001).The area under the curve of AEF,ECV and AEF combined with ECV were 0.623,0.887 and 0.907,and Youden index were 0.271,0.661and 0.678,respectively.The diagnostic model for the AEF combined with ECV was Y=-0.033×AEF-0.185×ECV+10.084(PTC was diagnosed when Y>0.697).Conclusion The spectrum CT quantitative parameters AEF combined with ECV could have a relative higher diagnostic value for PTC,which could be considered as imaging biomarker for the diagnosis of PTC.
Keywords：spectral CTpapillary thyroid carcinomaarterial enhancement fractionextracellular volumediagnosis
Publication Date：2024-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 138-142 )