Application of Micro-CT in whole-body fat scanning imaging of mice
HOU Bao
HUANG Shubing
HAN Peiyu
YAO Wenxi
CAI Weiwei
QU Xiuxia
SUN Haijian
QIU Liying
Abstract：Objective To investigate the effects of scanning voltage and X-ray filter on image quality and radiation dose of whole body fat scanning in mice.Methods Six C57BL/6 mice were selected,including three were normal control mice and three obese mice fed with high fat diet.Micro-CT was used to scan the whole body of mice,and the radiation dose under different scanning conditions was calculated.The subcutaneous and visceral fat were extracted by Analyze12.0 software,and the image quality and fat distribution were evaluated.Results The scanning results of normal mice and obese mice showed that under the scanning voltage of 70 kV and Al 1.0 mm X-ray filter,the boundary between mice subcutaneous fat and visceral fat was clear and without artifacts,with high image quality and low radiation dose.The subcutaneous fat and visceral fat of mice separated by analyze12.0 software were continuous and smooth with complete fat display.Conclusion This study provides a theoretical basis for the clinical study of subcutaneous fat and visceral fat in patients,and provides data reference for the selection of CT scan voltage and filter.Under the premise of reducing the scanning voltage and ensuring the image quality,the radiation dose to the patient was reduced to the maximum.
Keywords：micro-CTtube voltagefilterfatimage quality
Publication Date：2024-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 111-117 )