Advances in structural and functional magnetic resonance imaging of subjective cognitive decline
LI Yijie
HAN Yingmei
ZHANG Heng
LÜ Jing
ZHANG Yi
LIN Nan
QIAO Yingbo
WANG Feng
Abstract：Subjective cognitive decline is considered to be the first clinical manifestation of the Alzheimer's disease continuum,preceding mild cognitive impairment.Its cognitive changes are characterized by subtle cognitive decline and compensatory cognitive effort,and have been shown to be a high-risk stage of Alzheimer's disease.Studying people with subjective cognitive decline is important to understanding the pathological mechanisms of early Alzheimer's disease and identifying biomarkers associated with subjective cognitive decline,and early diagnosis and intervention can effectively improve patient outcomes.With the advent of advanced neuroimaging techniques such as positron emission tomography and MRI,a growing body of evidence is revealing alterations in brain structure and function associated with symptoms of subjective cognitive decline.This study mainly reviewed the current research status of diagnosis and prediction of subjective cognitive decline from the perspectives of structural magnetic resonance imaging,diffusion tensor imaging,functional magnetic resonance imaging and machine learning,in order to reveal its neurophysiological mechanism and provide imaging basis for early diagnosis.
Keywords：subjective cognitive declineAlzheimer's diseasemild cognitive impairmentmagnetic resonance imagingreview
Publication Date：2024-02-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 98-101 )