Relationship between CT imaging features of non-small cell lung cancer and expression of Ki-67 and vascular endothelial growth factor
YANG Kui
XU Peng
TIAN Jiaming
WANG Hanqing
Abstract：Objective To explore the relationship between CT imaging features of non-small cell lung cancer(NSCLC)and the expression of Ki-67 and vascular endothelial growth factor(VEGF),providing a theoretical basis for the clinical diagnosis,treatment,and prognosis of NSCLC.Methods A retrospective analysis of 112 patients diagnosed with NSCLC in our hospital from January 2018 to January 2023.Philips Brilliance 256iCT was used to examine CT imaging features,and the expression of Ki-67 and VEGF in NSCLC tissues was detected.The relationship between imaging features,clinical data(pathological type,gender,age,smoking history),Ki-67 and VEGF expression levels was analyzed.Results In the relationship between CT features and Ki-67 expression,the presence of spiculation sign,deep lobulation sign,arterial phase enhancement CT value≥20 Hu,venous phase enhancement CT value≥20 Hu,enlargement of mediastinal lymph nodes and diameter≥3 cm was associated with a high Ki-67 positive expression rate(P<0.05).The presence of calcification and pleural traction sign was associated with a low Ki-67 positive expression rate(P<0.05).Other indicators showed no statistical significance.In the relationship between CT features and VEGF expression,the presence of vessel convergence sign,significant enhancement in the arterial phase≥20 Hu,diameter≥3 cm,and enlargement of mediastinal lymph nodes was associated with a high VEGF positive expression rate(P<0.05).The presence of air bronchogram sign,deep lobulation sign,and diameter<3 cm was associated with a low VEGF positive expression rate(P<0.05).In the relationship between clinical data and Ki-67 and VEGF expression,males,those with a smoking history,and a high Ki-67 positive expression rate in patients,and a low Ki-67 positive expression rate in squamous cell carcinoma,were statistically significant(P<0.05).There was no statistical difference in VEGF expression between different clinical data groups(P>0.05).Conclusion CT imaging features in NSCLC patients are closely related to the expression of Ki-67 and VEGF,providing a certain predictive value for immunohistochemical marker expression.
Keywords：CT featuresnon-small cell lung cancerKi-67vascular endothelial growth factor
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 994-1000 )