Effect of NM23 expression on 18F-FDG PET/CT in non-small cell lung cancer radiotherapy schedule

XIA Luhua; CHONG Le; Li Hongyu; XIA Huan; QIAO Zheng; DONG Zhanfei; ZHAO Yanping; WANG Xinhua; CHANG Cheng

doi:10.12122/j.issn.1674-4500.2023.06.04

Abstract：Objective To analyze the influence of NM23 gene expression status on the biological behavior of non-small cell lung cancer and on radiotherapy planning.Methods A total of 107 patients with non-small cell lung cancer in the Cancer Hospital of Xinjiang Medical University were taken as the study subjects,and the radiotherapy protocols were formulated under PET/CT images,the general target area volume outlined under PET/CT images,and the amount of critical organs irradiated,which were divided into high NM23 expression group(n=43)and low NM23 expression group(n=64)according to the results of immunohistochemistry,and the differences in the maximal standardized uptake value of metabolic parameters of PET/CT,the PET/CT images,the volume of the radiotherapy macroscopic target area outlined under the images,and the differences in the amount of critical organs irradiated were compared.Results The maximum standardized uptake value of metabolic parameters measured in PET/CT in the NM23 high-expression group was smaller than that of the low-expression group,and the difference was statistically significant(P<0.05).In the radiotherapy plans formulated by the NM23 low-expression group and the NM23 high-expression group,the volume of the macroscopic target area,and the volume of the organs at risk of radiation were smaller than that of the low-expression group in the NM23 high-expression group,and the differences were statistically significant(P<0.05).Conclusion In-depth understanding of NM23 gene expression and its biological behavior in NSCLC patients,and the use of PET/CT in the development of radiotherapy plans can provide more reference information for the precise sculpting of radiotherapy targets in non-small cell lung cancer patients.