Predictive value of TIMP-2 combined with IGFBP-7 for acute kidney injury in critically patients
LIQianqin
ZHENGShaoyi
XURongning
LINXuefeng
XIAOZezhou
ZHUPeng
WANGRuiling
Abstract：ObjectiveTo explore the prediction efficiency of TIMP-2 combined with IGFBP-7 for the early prediction ofAKI in critical patients.MethodsA comprehensive systemic search was carried out in MEDLINE, EMBASE, Web of Science, Clinical Trials.gov, Cochrane Library, Google Scholar, and 13 related studies were screened.The bivariate generalized nonlinear mixed-effect model and the hierarchical summary receiver operating characteristic model were used to estimate the pooled sensitivity, specificity, and summary receiver operating characteristic curve of TIMP-2 plus insulin-like growth factor-binding protein(IGFBP)-7. Results The pooled area under the curve (AUC) of [TIMP-2] × [IGFBP-7] for predicting AKI was 0.84(95% CI, 0.78-0.90). A hierarchical bivariategeneralized linear model with a cutoff of 0.3 indicated a sensitivity of 86% and specificity of 57%; with a cutoff of 2.0 indicating sensitivity of 37% and the specificity of 91%. ConclusionTIMP-2 combined with IGFBP-7 have effective AUC, sensitivity and specificity to predict AKI for the postoperative patients and critical patients .
Keywords：acute kidney injurytissue inhibitor of metalloproteinase 2insulin-like growth factor-binding protein 7cardiac surgerysevere patient
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 227-233 )