Molecular mechanism of autophagy in neuropathic pain
WANGWenmiao
JIANGJiuliang
MANing
SUNYing
DONGKai
XUYue
TANWenbin
LIUHongsheng
Abstract：Neuropathic pain is a kind of pain directly caused by the injury or disease of somatosensory nervous system, involving a variety of cells, molecules and pathways. Autophagy is involved in the physiological and pathological process of neuropathic pain, which may be related to inflammatory factors, oxidative stress and other mechanisms. Studies have found that mTOR, TLR, P62, Wnt, JNK, HIF, etc. all participate in the autophagy process of neuropathic rational pain. In epigenetics, mirna-195 inhibits autophagy caused by peripheral nerve injury, which in turn intensifies neuropathic pain. The pathogenesis of autophagy in neuropathic pain is complicated, which challenges the research and development of drugs for autophagy in neuropathic pain. In this review, progress of the autophagy and neuropathic pain were summarized.
Keywords：neuropathic painautophagymolecular mechanism
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 222-226 )