Combined detection of multiple biomarkers in gynecological tumors by protein chip technology
HE Bao-xian
CHEN Shu
LIU Fang
JIANGg Hong
FENG Cui-lan
TANG Dong-sheng
Abstract：The present study aims to explore the significance of the combined detection of multiple serum tumor-markers using protein biochip technique in patients with gynecological tumors. The serum levels of 12 tumor markers, including CA19-9, NSE ,CEA, CA242 ,CA125, CA153, AFP, ferritin, free-PSA, PSA, HGH and β-HCG were measured using the multiple-tumor marker protein chip system (HD-2001A) in 81 cases of gynecologic tumors(including ovarian cancer, cervical cancer, endometrial cancer), 100 cases of benign lesions and 73 cases of healthy adults. The differences among the gynecological malignancy group, benign lesions group and normal control group were analyzed. The serum levels and positive rates of CEA and CA199 in patients with gynecological malignancy were significantly higher than those in patients with benign lesions and healthy adults (p< 0.05). The serum levels of CA199 and CA125 in cases with ovarian cancer were significantly higher than those of the normal control group(p<0.05), and the serum levels of CEA in cases with uterine cervical cancer and endometrial carcinoma were also significantly higher than those of the normal control group(p<0.05). The combined detection of CA199 and CA125 can improve the positive rate of ovarian cancer. Combined detection of multiple serum tumor-markers using protein biochip technology can significantly increase the diagnostic sensitivity for gynecological malignancy. The combined detection of CA199 and CA125 play important roles in the positive detective rates in population with high risk of gynecological malignancy.
Keywords：gynecological tumorsmultiple biomarkersprotein chipmolecular diagnosis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 41-45 )