The roles of chemokine CXCL16 and its receptor CXCR6 in malignancies
TANG Hong-ping
LIU Fang
TANG Dong-sheng
ZHAO Tong
Abstract：Chemokines play important roles in the progressing of malignancies, such as carcinogenesis, development, metastasis, formation of tumor microenvironment and anti-tumor immunity. A recently founded chemokine CXC chemokine ligand 16 (CXCL16)and its receptor CXCR6 are receiving increasing attention. It was reported that CXCL16/CXCR6 were over-expressed in many malignancies, could stimulate growth, metastasis and recurrence in some tumors, while played opposite role in others. Moreover, CXCL16/CXCR6 were involved in the formation of tumor microenvironment and stimulate anti-tumor immunity by inducing immune cells, such as CD4+/CD8+ T lymphocyte, NK lymphocyte and so on. Further defining the roles and related molecular mechanisms of CXCL16/CXCR6 in malignancies would be helpful to promote the anti-tumor study.
Keywords：chemokinemalignancyCXCL16CXCR6
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 29-35 )