Analysis on the Effect of Carvacrol-assisted Gentamicin on Killing Pseudomonas aeruginosa
WANG Yu-chan
CHEN Jia-jun
CHEN Dan-yan
LIU Jun-hui
WANG Yan
Abstract：Pseudomonas aeruginosa is a multidrug-resistant bacterium that can cause a variety of diseases in poultry and livestock,and its outer membrane permeability is much lower than that of other bacillaceae,which is an important reason for its drug resistance and clinical treatment failure.By testing the killing effect of different concentrations of carvacrol and gentamicin on Pseudomonas aeruginosa under different treatment conditions(including concentration,time and medium),the degree of damage to the cell membrane of Pseudomonas aeruginosa was evaluated,and the killing effect of carvacrol as an adjuvant on gentamicin against Pseudomonas aeruginosa PAO1 was further explored.The results showed that with the assistance of 0.01%carvacrol,the dosage of gentamicin could be reduced by 100 times,and the bactericidal effect on Pseudomonas aeruginosa could be significantly enhanced within 1 hour.The auxiliary effect was adaptable to different media,and also had a certain broad-spectrum activity under different antibiotics,and could improve the killing effect of gentamicin on the clinical Pseudomonas aeruginosa.The results of this study provided strong data support for the application of carvacrol as an antimicrobial adjuvant in reducing the drug resistance of Pseudomonas aeruginosa.
Keywords：Bacterial resistancePseudomonas aeruginosaAdjuvantsCarvacrolAuxiliary
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 53-59 )