Synthesis of a temperature-responsive multimodal motion microrobot capable of precise navigation for targeted controllable drug release
ZHAO Xuhui
LIU Mengran
CHEN Xi
HUANG Jing
LIU Yuan
XU Haifeng
Abstract：Objective To synthesize a temperature-responsive multimodal motion microrobot(MMMR)using temperature and magnetic field-assisted microfluidic droplet technology to achieve targeted drug delivery and controlled drug release.Methods Microfluidic droplet technology was utilized to synthesize the MMMR by mixing gelatin with magnetic microparticles.The microrobot possessed a magnetic anisotropy structure to allow its navigation and targeted drug release by controlling the temperature field and magnetic field.In the experiment,the MMMR was controlled to move in a wide range along a preset path by rotating a uniform magnetic field,and the local circular motion was driven by a planar rotating gradient magnetic field of different frequencies.The MMMR was loaded with simulated drugs,which were released in response to laser heating.Results Driven by a rotating magnetic field,the MMMR achieved linear motion following a predefined path.The planar gradient rotating magnetic field controlled circular motion of the MMMR with an adjustable radius,utilizing the centrifugal force generated by rotation.The drug-loaded MMMR successfully reached the target location under magnetic guidance,where the gelatin matrix was melted using laser heating for accurate drug release,after which the remaining magnetic particles were removed using magnetic field.Conclusion The MMMR possesses multimodal motion capabilities to enable precise navigation along a predefined path and dynamic regulation of drug release within the target area,thus having great potential for a wide range of biomedical applications.
Keywords：drug deliverymicrorobotmagnetic anisotropymultimodal motionmicrofluidic synthesis
Publication Date：2025-08-20
Online Publishing Date：2025-09-15(First online date of this platform, not the publication date of the document)
Pages：10( 1758-1767 )