Racial differences in treatment and prognosis of gastric signet ring cell carcinoma:analysis based on SEER and TCGA databases
FANG Shangping
LIU Jiameng
YUE Xingchen
LI Huan
Li Wanning
TANG Xiaoyu
BAO Pengju
Abstract：Objective To analyze the differences in the prognosis of gastric signet ring cell carcinoma(SRCC)among different races using the US Surveillance Epidemiology and End Results(SEER)database and The Cancer Genome Atlas(TCGA)database.Methods We analyzed the data of patients with gastric SRCC from the SEER database from 2000 to 2020,and divided the patients into cohorts of whites,blacks,Asians or Pacific Islanders,American Indians/Alaska Natives according to their race.The prognosis and treatment of the cohorts were evaluated using baseline demographic analysis,Kamplan-Meier survival curve,and nomogram analysis.Results We analyzed the data of a total of 2058 patients,including 8.6%blacks,72.4%whites,16.6%Asians or Pacific Islanders,1.0%American Indians/Alaska Natives,and 1.4%other races.The tumor grade varied among different races,and the prevalence and survival rates of patients differed significantly across races.The differences in the white cohort were the most prominent,and all the differences were statistically significant(P<0.05).Racial differences were also noted in patient management and prognosis.Conclusion There are racial differences in tumor grades and prognosis of gastric SRCC,and these differences provide evidence for optimizing clinical diagnosis and treatment strategies for this malignancy.
Keywords：signet ring cell carcinomaracial differencesSEER analysiscolumnar plotsTCGA database
Publication Date：2025-08-20
Online Publishing Date：2025-09-15(First online date of this platform, not the publication date of the document)
Pages：12( 1706-1717 )