Structure and function of B-cell linker and its role in the development of B cell-related diseases
XIAO Bin
LI Jiaying
ZHOU Mengsi
LI Xiaoqing
HUANG Xiaoyan
HANG Jianfeng
SUN Zhaohui
LI Linhai
Abstract：B cell linker (BLNK) is a key linker protein of B cell receptor (BCR) signaling pathway.BLNK participates in the regulation of PLC-γactivity and the activation of Ras pathway through its typical structure and interaction network with other proteins, and is thus widely involved in the regulation of B cell proliferation, differentiation, apoptosis and signal transduction.Furthermore, it is closely related to anaphylactic diseases, multiple sclerosis, chromosomal aneuploidy, aneuglobulinemia, B lymphocytic leukemia and lymphoma.Herein we review the structure and biological function of BLNK and its role in B cell-related diseases.BLNK can cooperate with a series of effective proteins to activate BCR signaling pathway, thereby regulating the development, maturation and function of B cells.The functional mutation of BLNK can destroy the homeostasis of B cells and affect the development and maturation of B cells, which leads to the occurrence of B cell related diseases.A comprehensive understanding of the biological functions of BLNK not only provides insights into the pathogenesis of B cell-related diseases, but also inspires new ideas and helps to find breakthroughs for the treatment of these diseases with BLNK as the therapeutic target.
Keywords：B-cell linkerB cell receptorsignaling pathwaydifferentiationB cell-related diseases
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 253-256,封3 )