Expression of phosphoglycerate kinase 1 in endometrial carcinoma and its association with patients' outcome
LIN Li
JIANG Qingping
LIN Dan
CHEN Wei
JIANG Huiping
LIU Chunhua
XIAO Yanyi
ZHU Litong
GUO Suiqun
Abstract：Objective To investigate the expression of phosphoglycerate kinase 1(PGK1)and its prognostic value in endometrial carcinoma(EC).Methods The expression of PGK1 was detected immunohistochemically in 30 normal endometrium and 130 EC specimens. The relationship between PGK1 protein expression and the clinicopathological features of the patients was evaluated.Results Immunohistochemical analysis revealed low PGK1 expression in 55.4%(72/130)and high PGK1 expression in 44.6% (58/130) of the EC specimens, as compared with the rates of 90% (27/30) and 10% (3/30) in normal endometrium, respectively (P<0.001). PGK1 expression was significantly correlated with FIGO stage (P<0.001), histological grade (P=0.002) and lymph node metastasis(P<0.001).Kaplan-Meier survival analysis indicated that patients with a high PGK1 expression had a shorter overall survival rate than those with a low PGK1 expression (P<0.001). Multivariate analysis showed that a high PGK1 expression was not the independent predictor of the prognosis of EC(P=0.077).Conclusion A high expression of PGK1 is associated with aggressive and metastatic behaviors of EC, and detection of PGK1 provides assistance in evaluating the prognosis of patients with EC.
Keywords：endometrial carcinomaPGK1immunohistochemistry
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 471-476 )