Plasma mannan-binding lectin and MBL-associated serine protease 2 in patients with hepatocellular carcinoma
LI Jie
ZHU Lingyan
ZUO Daming
ZHANG Liyun
LU Xiao
CHEN Zhengliang
ZHOU Jia
Abstract：Objective To detect the plasma levels of mannan-binding lectin(MBL)and MBL-associated serine protease-2(MASP-2) in patients with hepatocellular carcinoma (HCC) and explore their role in the tumorigenesis and progression of HCC. Methods The plasma levels of MBL and MASP-2 were detected by enzyme-linked immunosorbent assay in 64 HCC patients and 30 healthy control subjects. The correlation of MBL and MASP-2 with the clinical parameters of HCC patients were analyzed.Results The plasma levels of MBL(P=0.014)and MASP-2(P=0.002)were significantly higher in HCC patients than in the healthy controls, but the MBL-to-MASP-2 ratio did not differ significantly between the two groups. In HCC patients, plasma MBL level was positively correlated with vascular invasion(r=0.253,P=0.047)and total bilirubin level(r=0.283,P=0.024). The plasma level of MASP-2 was positively correlated with TNM stage (r=0.276, P=0.027) and negatively correlated with plasma albumin level (r=0.-0.317, P=0.015). ROC curve analysis revealed an area under curve of 0.665 for MBL(P=0.010) and 0.694 for MASP-2(P=0.003).The sensitivities of MBL and MASP-2 were 50% and 89.1% in the diagnosis of HCC,respectively. Conclusion MBL and MASP-2 are associated with the inflammatory state and disease progression in patients with HCC.
Keywords：hepatocellular carcinomamannan-binding lectinserine proteasemannan-binding lectin complement
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1667-1672 )