Association between hypertriglyceridemic waist-to-height ratio phenotype and chronic kidney disease in a community population in South China:a cross-sectional study
SHAO Xiaofei
WU Bifang
LIU Aiqun
LI Bin
LI Yongqiang
ZHOU Qin
ZOU Hequn
Abstract：Objective To investigate the relationship between hypertriglyceridemic waist-to-height ratio phenotype (HWHtR) and chronic kidney disease (CKD) in a community population in South China. Methods A cross-sectional study was conducted among 2142 residents in Zhuhai (Guangdong Province, China) from June to October of 2012. The HWHtR phenotype was defined as a waist-to-height ratio(WHtR) ≥0.55 and triglyceride level ≥2.0 mmol/L, based on which the participants were divided into HWHtR group and non-HWHtR group.CKD was defined as an eGFR<60 mL/min per 1.73 m2 or an ACR ≥30 mg/g. A logistic regression model was established to investigate the relationship between chronic kidney disease and HWHtR phenotype.Results Compared with the non-HWHtR group,the HWHtR group had a higher prevalence of chronic kidney disease (11.1% vs 33%, P<0.001). Analysis using the logistic regression model showed that HWHtR was significantly associated with CKD in the unadjusted analyses(OR=3.23,95% CI:2.32-4.48,P<0.001).After adjustment for age, sex,history of hypertension,history of diabetes,systolic blood pressure,diastolic blood pressure,drinking,physical exercise, education and current smoking, HWHtR was significantly associated with CKD (OR=2.36, 95% CI: 1.52-3.67, P<0.001); the association of HWHtR and CKD was still significant after further adjustment for BMI (OR=2.12, 95% CI: 1.34-3.35, P<0.001). Conclusion Our finding suggests that HWHtR is associated with CKD in this community population.
Keywords：hypertriglyceridemic waist-to-height ratio phenotypechronic kidney diseasecommunity population
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1382-1385 )