A novel method for quantitative measurement of orbital fat volume based on magnetic resonance images
CAI Qiuyue
CHEN Zhiyi
JIANG Wei
LUO Yaosheng
LI Zhangfang
HU Shidi
SHEN Jie
Abstract：Objective To establish a new method for rapid and quantitative measurement of orbital fat volume based on magnetic resonance imaging (MRI) data.Methods We collected MRI data from normalized mold and patients with the diagnosis of thyroid-associated ophthalmopathy (TAO).The cross-sectional areas of the orbital fat on each MR image slice were measured to calculate the fat volume on each slice and then the total orbital fat volume.We recorded the time for completing the measurement and assessed the precision,reliability,repeatability and interoperator variations of the results.Results This MRI data-based method allowed precise measurement of the orbital fat volumes with an absolute value of the mean percentage difference ＜1％.This method was fast and the results showed a good repeatability (with CVs ＜1％),a high reliability (ICC=0.996,95％ CI:0.985-0.999) and a high interoperator concordance (95％ CI of the Bland-Altman:-0.54-0.90).Conclusion The novel method we established for orbital fat volume measurement is rapid,accurate,reliable and reproducible with a low learning cost for clinical use.
Keywords：orbital fat volumesthyroid-associated ophthalmopathymagnetic resonance imagingquantitative measurement
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1248-1251 )