Expression of Wnt and integrin pathways in colorectal laterally spreading tumors and their correlation with endoscopic subtypes
WU Jie
HUO Jirong
WANG Dong
WANG Chunlian
L(U) Liang
Abstract：Objective To investigate the expression of Wnt and integrin pathways in colorectal laterally spreading tumors (LSTs) and their correlation with the different endoscopic subtypes of LSTs to better understand the special growth mechanism of LSTs.Methods Fifty-two patients with colorectal LSTs were randomly selected from the cases diagnosed between January 1,2010 and June 10,2015 in our hospital,including 37 of nodular mixed type (LST-G-M),60 of homogeneous type (LST-G-H),5 of fiat elevated type (LST-NG-FE),and 4 of pseudodepressed type (LST-NG-PD).The expression of β-catenin,phosphoGSK-3β,paxillin and ILK in 52 colorectal LSTs and 15 protruded adenomas (PAs) were investigated by immunohistochemical staining.The correlation of β-catenin,phospho-GSK-3β,paxillin and ILK expressions among the endoscopic subtypes of LSTs were analyzed.Results β-catenin expression was significantly higher in LSTs than in Pas (P＜0.05).β-catenin,phospho-GSK-3β,paxillin and ILK expressions were significantly higher in LST-NG-PD than in Pas (P＜0.05).The expressions of β-catenin,phospho-GSK-3β and ILK expression were significantly correlated in LSTs (P＜0.05) but not in PAs (P＞0.05).Conclusion The macroscopic feature of LST-NG-PD may result from a special mechanism of development distinct from other endoscopic subtypes;ILK may play a role in regulating Wnt signaling in LSTs.
Keywords：laterally spreading tumorWnt pathwayintegrin pathwayβ-cateninendoscopic subtypes
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 1234-1241 )