Effect of electroacupuncture on proprioception in cynomolgus monkeys after unilateral anterior cruciate ligament injury
ZHANG Lei
LI Yikai
QI Ji
ZHANG Shaoqun
PING Ruiyue
ZHOU Xin
YU Lin
LIU Ruifeng
FU Shijie
Abstract：Objective To study the effect of electroacupuncture on proprioception in cynomolgus monkeys after unilateral anterior cruciate ligament (ACL) injury.Methods Twenty-seven cynomolgus monkeys were randomized equally into 3 groups,namely unilateral ACL injury with electroacupuncture group,unilateral ACL injury model group and blank control group.One week after modeling,the monkeys in electroacupuncture group were treated daily for 12 weeks with electroacupuncture at the acupoints Wei Yang,Yin Gu,Xi Yangguan and Qu Quan.At 4,8,and 12 weeks during the treatment,the changes in the somatosensory evoked potentials (SEPs) and motor nerve conduction velocity (MCV) of the nerves of the ACL were examined with neural electrophysiological method;the changes in the morphology and the total and variable number of the proprioceptors in the ACL were observed with gold chloride staining.Results In the mokeys in the model group,the incubation period of the SEPs and MCV on the injured side of the knee were significantly extended and the amplitudes were decreased with the passage of time (P＜0.05).Intervention with electroacupuncture significantly reduced the incubation period and increased the amplitudes of the SEPs and MCV (P＜0.05).The total number of the proprioceptors in the ACL was significantly decreased and the variable number of the proprioceptors in ACL was increased with time in the monkeys in the model group (P＜0.05);electroacupuncture intervention obviously slowed the reduction rate of total number of the proprioceptors (P＜0.05) but without affecting the variable number of the proprioceptors (P＞0.05).Conclusion ACL injury causes attenuation of the proprioception on the injury side,and electroacupuncture intervention can produce a positive effect on the proprioception in cynomolgus monkeys.
Keywords：anterior cruciate ligamentproprioceptionproprioceptorelectroacupuncture
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 1171-1177 )