Correlation between cytochrome 3A4+894C＞T P450 gene polymorphism and outcomes of coronary intervention in patients with acute coronary syndrome
Abstract：Objective To investigate the relationship between plasma cytochrome P450 3A4 (CYP3A4) 894C＞T gene polymorphism and the risk of recurrence of adverse cardiac events after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS).Methods A total of 275 patients with ACS received standard dual antiplatelet therapy and PCI.Platelet aggregation rate (PAR) was detected in each patient before and 7 days after administration of the anti-platelet drugs.Single nucleotide polymorphism of CYP3A4 gene 894C＞T was detected with PCR and microarray technique.The number of coronary artery lesions was determined by PCI and the Gensini score was calculated.The patients were followed up for 3-12 months after discharge.Results No significant difference was found in CYP3A4 gene polymorphism between patients with clopidogrel resistance (CR group) and those without CR (NCR group) (P＞0.05).Multivariate logistic regression analysis showed that CYP3A4 gene 894C＞T polymorphism was not correlated with CR in patients with ACS (OR 1.359,P＞0.05).During the follow-up,the incidence of cardiovascular events was significantly higher in CR group than in NCR group (P＜0.05),but this difference was not related to the mutation type of 894C＞T locus of CYP3A4 gene.Conclusion The CYP3A4 gene 894C＞T polymorphism is not associated with the effect of anti-platelet therapy and the risk of cardiovascular event in patients with ACS following PCI.
Keywords：CYP3A4 gene polymorphismacute coronary syndromeclopidogrel resistance percutaneous coronary intervention
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 261-265 )