Early outcomes of elective surgery for colon cancer with preoperative mechanical bowel preparation:a randomized clinical trial
HU Yanjie
LI Ka
LI Li
WANG Xiaodong
YANG Jie
FENG Jinhua
ZHANG Wei
LIU Yuwei
Abstract：Objective To compared the early outcomes of patients undergoing elective surgeries for colon cancer with and without preoperative mechanical bowel preparation. Methods Between July, 2014 and February, 2016, patients undergoing elective surgery for colon cancer with primary anastomosis were randomly assigned into control group with mechanical bowel preparation 12 h before surgery and treatment group without mechanical bowel preparation. Baseline data collection was completed within 12 h after the operation. The levels of hemoglobin, total protein, albumin, prealbumin and albumin/globulin ratio of the patients were recorded at 1 day before surgery and 1 day and 5 days after the surgery. The patients were followed up till 30 days after the surgeries and the complications were recorded. Results Seventy-six patients were assigned in the treatment group and 72 in the control group. Significant differences were found in the incidence of wound infection and intra-abdominal infection (P<0.05) but not in that of anastomotic leakage or early postoperative bowel obstruction (P>0.05) between the two 2 groups. The first flatus time (P=0.03) and prealbumin level on the first postoperative day (P=0.03) differed significantly between the two groups, but the operation time was similar between them (P=0.06). Conclusion In patients undergoing elective surgeries for colon cancer, preoperative mechanical bowel preparation is associated with increased postoperative complications, delayed recovery of intestinal motility and poorer nutrition status early after the operation.
Keywords：colon cancermechanical bowel preparationoutcomes
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 13-17 )