Expression of microRNA-155 in papillary thyroid carcinoma and its clinical significance
ZHU Youzhi
ZHENG Ke
ZHANG Huihao
CHEN Ling
WU Kunlin
REN Caihong
WANG Zongcai
KONG Lingjun
RUAN Weihong
CHEN Xiangjin
Abstract：Objective To investigate the correlation of microRNA-155 (miR-155) expression with clinicopathological features of patients with papillary thyroid carcinoma (PTC) and explore the value of miR-155 in prognostic assessment of PTC. Methods We collected 86 pairs of fresh PTC and adjacent tissues to examine the expression of miR-155 using fluorescent quantitative PCR. miR-155 expressions in the tissues were analyzed in relation to the clinicopathological features of the patients. Results Compared with the paired adjacent tissues, 69.8%(60/86) of the PTC tissues showed up-regulated miR-155 expression by 2.63± 2.73 folds. Up-regulated miR-155 expressions were associated with a larger tumor size (1.66 ± 0.96 vs 1.19 ± 0.52 cm, P=0.021), a higher likeliness of extrathyroid invasion (56.7%vs 23.1%, P=0.004), a higher rate of lymph node metastasis (70%vs 46.2%, P=0.036), a more advanced TNM stage, and a higher rate of III-IV stage of the tumor (20%vs 0%, P=0.014). The expression level of miR-155 in PTC tissues was positively correlated with lymph node metastasis (r=0.531, P=0.001). Conclusion PTC patients with miR-155 over-expression tend to have a greater tumor size, a greater likeliness of extrathyroid involvement, a higher rate of cervical lymph node metastasis and a more advanced TNM stage. The high expression of miR-155 in the tumor may indicate a poor prognosis of PTC patients.
Keywords：thyroid tumorpapillary thyroid carcinomamicroRNA-155
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1364-1368 )