Propofol suppresses migration and invasion of breast cancer MDA-MB-231 cells by down-regulating H19
BAI Jianjie
LIN Chunshui
YE Huijin
GUO Peipei
WANG Wei
Abstract：Objective To explore the effect of propofol on H19 expression, migration and invasion of human breast cancer MDA-MB-231 cells in vitro. Methods MDA-MB-231 cells were randomly divided into 5 groups for treatment with basal medium, DMSO, or propofol at concentrations of 25, 50, and 100μmol/L. H19 expression of the treated cells was assessed with RT-PCR, and the changes of cell motility, migration and invasion were evaluated with wound-healing assay and Transwell assays. Results Treatment of the cells with 25, 50, and 100μmol/L propofol for 24 h down-regulated H19 by 17.83%, 37.50%and 63.67%(P<0.05), and suppressed cell motility by 13.46%, 36.54%and 46.17%(P<0.05), cell migration by 27.93%, 57.90%and 76.51% (P<0.05), and cell invasion by 25.72%, 53.32% and 81.43% (P<0.05), respectively. Conclusion Propofol-induced cell migration and invasion suppression are partially mediated by down-regulating H19 in MDA-MB-231 cells in vitro.
Keywords：propofoltumor metastasisH19breast cancer
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1255-1259 )