Value of serum IgA/C3 ratio in the diagnosis of IgA nephropathy and its correlation with the clinicopathological features
ZHU Shuangshuang
LI Yongqiang
ZHOU Shulu
WEI Qingzhu
DENG Kangping
WANG Xiaohong
LI Bin
LIU Jianghuan
LIU Xinyu
ZHANG Ying
SHAO Xiaofei
LIU Aiqun
WU Bifang
ZHAO Zhihong
XU Xiaomeng
LIN Hanfei
LIU Qin
LI Jiamin
WANG Honglei
ZHOU Qin
ZHU Chaoya
L Daoyuan
XIA Yue
ZOU Hequn
Abstract：Objective To investigate the value of serum IgA/C3 ratio in the diagnosis of IgA nephropathy and explore its relationship with the clinicopathological features of the patients. Methods Sixty-six patients with IgA nephropathy, 111 with other glomerular diseases, and 40 healthy control subjects without kidney disease were tested for serum IgA and C3 levels using CRM470 adjusted standardized immune turbidimetric method, and the IgA/C3 ratio was calculated. According to Oxford and Lee's classification criteria, we analyzed the pathological grades of the renal biopsy samples from patients with IgA nephropathy. The ROC curve was used to assess the value of serum IgA and IgA/C3 ratio in predicting IgA nephropathy. Results Patients with IgA nephropathy had an elevated serum IgA/C3 ratio than those with other glomerular diseases and the control subjects, with an area under the ROC curve of 0.776. An elevated serum IgA/C3 ratio was not found to significantly correlate with the pathological grade of renal biopsy samples in patients with IgA nephropathy. Conclusion In the absence of renal biopsy findings, serum IgA/C3 ratio can help in the diagnosis of IgA nephropathy.
Keywords：IgA nephropathyserum IgA/C3 ratioserum IgA
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1683-1688 )