Impact of visit-to-visit blood pressure variability on vascular function in elderly hyper-tensive patients
LIU Qiyun
LIU Yingying
HAN Junli
LI Jianghua
DONG Shaohong
Abstract：Objective To assess the relationship between visit-to-visit blood pressure (BP) variability (BPV) and vascular endothelial function in a cohort of elderly hypertensive patients. Methods A total of 174 elderly patients with essential hypertension were included in the study. The participants had their office BP measured during the 12-month follow-up. Right brachial artery diameter was assessed at rest, during reactive hyperemia (flow- mediated dilation, FMD), and after nitroglycerin administration (nitroglycerin- mediated dilation, NMD). The participants were divided into two groups according to FMD%or FMD/NMD ratio. The correlations between BPV and endothelial function were analyzed by univariate analysis and multiple linear regression analysis. Results The participants classified as having a decreased endothelial function according to FMD/NMD ratio had significantly lower FMD%and higher BPV and NMD%(P<0.05). The percentage of CCBs use in normal endothelial function group was significantly higher than that in decreased endothelial function group (79.55%vs 63.95%, P<0.05). Multiple linear regression analysis revealed a significant negative association between FMD/NMD ratio and BPV, and this association remained significant after adjustment for age, body mass index, and mean BP levels. Conclusions FMD/NMD ratio is a better marker of endothelial function than FMD, and an increased visit-to-visit variability of BP is associated with a decreased endothelial function.
Keywords：hypertensionblood pressure variabilityendothelial function
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1320-1324 )