Association of single nucleotide polymorphisms in the promoter of GABAA receptor β2 subunit gene with schizophrenia
ZHOU Lin
ZONG Lu
ZHANG Lulu
DENG Cong
ZHAO Cunyou
Abstract：Objective To investigate the genetic association between schizophrenia and the polymorphism of GABAA receptorβ2 subunit (GABRB2) gene. Methods A population association analysis was performed of 5 single nucleotide polymorphisms (SNPs) in the proximal promoter of GABRB2 gene by PCR and sequencing of the genomic DNA in a cohort of 172 schizophrenics and 167 controls of Chinese Han nationality. Results One out of the 5 SNPs, namely rs3811996, was found to be significantly associated with schizophrenia especially in the male cohorts, where the heterozygous genotypes (A/G) and minor allele G displayed lower frequencies in case group than in the controls. Conclusion We found a new risk, SNP rs3811996, for paranoia schizophrenia, which further supports the importance of genetic variations of GABRB2 in the etiology of schizophrenia.
Keywords：schizophreniaGABRB2 genepromotersingle nucleotide polymorphism
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 256-259 )