Changes of circulating hematopoietic progenitor cells in patients undergoing coronary artery bypass graft surgery
ZHANG Lin
GAO Changqing
WANG Rong
XIAO Cangsong
WU Yang
Abstract：Objective To evaluate the changes of circulating hematopoietic progenitor cells (cHPCs) in patients undergoing coronary artery bypass graft (CABG) surgery. Methods Fifty-one patients scheduled to undergo elective CABG surgery were prospectively enrolled in this study. Blood samples were collected at baseline and at 1, 3, and 5 days after the surgery. CD34+CD45dim,CD133+CD45dim, and CD34+CD133+ CD45dim cells were measured by flow cytometry. The functionality of the circulating progenitor cells were studied in vitro using clonogenic and migration assays. Results All the elective patients showed a significant postoperative increase of CD34+CD45dim (1.51 ± 1.26 vs 2.02 ± 1.16, P=0.036) and CD133+CD45dim cells (1.16 ± 0.85 vs 1.65 ± 0.99, P=0.008) irrespective of on-pump or off-pump CABG. The perioperative changes of the cHPCs was more significant in patients undergoing on-pump surgery than those having off-pump surgery. Conclusion In patients undergoing elective cardiac surgery, cHPC level increased early after the surgery but recovers the normal level over time.
Keywords：circulating hematopoietic progenitor cellscoronary artery bypass graftcoronary artery disease
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1574-1577 )