Effect of statins on occurrence of infection and infection-related mortality:a meta-analysis
WANG Guizuo
ZHANG Yonghong
XIE Xinming
HAN Dong
WU Yuanyuan
LI Shaojun
LI Fengjuan
LI Manxiang
Abstract：Objective To systematically review whether statins can reduce the risk of infection and infection-related mortality. Methods We searched the Cochrane Library, MEDLINE, EMBASE, PubMed, Elsevier and CBM databases for randomized placebo-controlled trials of statins published by September 2013, and each trial enrolled at least 100 participants with follow-up for at least 4 weeks. Two reviewers independently assessed the quality of the included studies and extracted the relevant data for analysis using Stata 12.0 software. Results Sixteen trails involving a total of 48973 patients were included in our meta-analysis. The results showed that statins significantly reduced the risk of infection (OR=0.93, 95% CI 0.89 to 0.98, P=0.004) compared to placebo but did not significantly lower infection-related mortality (OR=0.96, 95% CI 0.82 to 1.12, P=0.592). Conclusion Statins can significantly reduce the risk of infection but does not lower infection-related mortality.
Keywords：statinsrisk of infectioninfection-related mortalityrandomized controlled trialsmeta-analysis
Publication Date：2014-01-01
Pages：6( 988-993 )