Risk factors of level Ib lymphadenopathy in nasopharyngeal carcinoma
YUAN Gongjun
ZHENG Xiaokang
ZHU Xiaoxia
WANG Zhe
SONG Wen
ZHANG Hong
SHA Zhou
Abstract：Objective To analyze the risk factors for level Ib lymph node enlargement on CT in patients with nasopharyngeal carcinoma (NPC) and provide clinical evidence for defining the indications of prophylactic level Ib irradiation. Methods A total of 435 newly diagnosed NPC patients receiving radiotherapy in Nanfang Hospital in the past 2 years were enrolled in this analysis. The correlations were analyzed with Logistic regression between level Ib lymphadenopathy and the clinical risk factors including T stage, N stage, diameter of level II lymph nodes, submandibular gland involvement, nasal cavity involvement, oropharyngeal involvement, and involvement of 4 or more lymphatic drainage regions. Results Univariate analysis showed that level Ib lymphadenopathy were positively correlated with N stage (P=0.023), submandibular gland involvement (P=0.045), and level II lymph node diameter (P<0.001). Multivariate Logistic regression analysis suggested a significant correlation only between the diameter of the level II lymph nodes and level Ib lymphadenopathy (P=0.013). Conclusion Level Ib lymphadenopathy is positively correlated with the size of ipsilateral level II lymph nodes in NPC patients.
Keywords：nasopharyngeal neoplasmslymph node metastasisradiotherapyxerostomia
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 983-987 )