Inhibitory activities of 3-trifluoromethyl benzamide derivatives against the entry of H5N1 influenza viruses
ZHU Zhibo
CAI Yun
YANG Jie
LI Xianglian
LI Runming
LIU Shuwen
Abstract：Objective To study the inhibitory activities of 3-trifluoromethyl benzamide derivatives against the entry of H5N1 influenza viruses. Methods The lead compound was structurally modified to obtain 3 compounds with inhibitory activities against H5N1 influenza viruses. Specs compound librany was screened and 4 compounds were identified to have such inhibitory activities. The inhibitory activities of these compounds were tested at a celluar level against H5N1 influenza viruses. Results and Conclusion The compounds 1a, 1b, 1e and 1f showed signifcant inhibitory activities against the entry of A/AnHui/1/2005 pseudovirus into the target cells with an IC50 value of 4.7±0.3μmol/L.
Keywords：H5N1 avian influenza virusinfluenze virus entry inhibitorhemagglutininbenzamide
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 961-964 )