Association between CISH polymorphisms and susceptibility to chronic hepatitis B in Chinese Han population
ZHANG Xin
SUN Xuehua
ZHOU Zhenhua
LI Man
GAO Yueqiu
Abstract：Objective To investigate the association between rs414171 single nucleotide polymorphisms (SNP) of cytokine-inducible src homology 2 domain protein (CISH) and the susceptibility to chronic hepatitis B. Methods A total of 233 Chinese Han patients with chronic hepatitis B and 148 age-and sex-matched healthy controls were enrolled in this case-control study. The SNP rs414171 was genotyped by Sequenom MassArray-IPLEX to analyze the relationship between rs414171 and chronic hepatitis B. Results The distribution of SNP rs414171 allele and genotype frequencies showed no significant difference between the patients and healthy controls (P>0.05). Conclusion CISH rs414171 is not significantly associated with the susceptibility to chronic hepatitis B in Chinese Han population.
Keywords：cytokine-inducible src homology 2 domain proteinchronic hepatitis Bsingle nucleotide polymorphismssusceptibility
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 468-471 )