GM6001 suppresses scar formation after glaucoma filtration surgery in rabbits
SHEN Ying
WU Wei
LU Xiaohe
GUO Wenqi
Abstract：Objective To study the effect of matrix metalloproteinases inhibitor GM6001 in suppressing scar tissue formation in the filtering passage after glaucoma filtration surgery. Methods Twenty- four pigmented rabbits (48 eyes) underwent trabeculectomy followed by subconjunctival injection of GM6001 in the right eye (treated eyes) and injection of PBS in the left eye (control) once a day. The intraocular pressure was monitored postoperatively and proliferating cell nuclear antigen (PCNA)- and α- smooth muscle actin (α- SMA)- positive cells in the filtering pathway were detected using immunohistochemistry. Results On postoperative days 7, 14, 21, and 28, the intraocular pressure was significantly lower in the treated eyes (GM6001) than in the control eyes (P<0.01). The counts of PCNA-andα-SMA-positive cells were also significantly lowered in the treated than in the control eyes (P<0.01). Conclusion GM6001 can inhibit excessive proliferation of the fibroblasts in the filtering pathway to suppress scar tissue formation and prolong the existence of the functional filtration bleb in rabbits.
Keywords：matrix metalloproteinases inhibitorGM6001proliferating cell nuclear antigenα-smooth muscle actin
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 241-245 )