Volume changes of cortical and subcortical reward circuitry in the brain of patients with type 2 diabetes mellitus
CHEN Zhiye
LI Jinfeng
LIU Mengyu
MA Lin
Abstract：Objective To elucidate the volume changes of cortical and subcortical reward circuitry in patients with type 2 diabetes mellitus. Methods High-resolution three-dimensional T1-weighted fast spoiled gradient recalled echo MRI images were obtained from 16 patients with type 2 diabetes mellitus and 16 normal controls, and 11 type 2 diabetic patients also received the same MRI scans after insulin therapy for 1 year. Volumetric analysis was performed and analysis of covariance and paired t test were applied. Results A decreased volume was found in the left insular lobe, left nucleus accumbens area, right hippocampus, putamen and amygdala in type 2 diabetic patients compared with normal controls (P<0.05). After insulin therapy for 1 year, an increased volume of bilateral cortical reward structures was observed (left, 33.65 ± 3.66 ml;right, 33.35 ± 4.25 ml) compared the baseline level (left, 31.45 ± 2.90 ml; right, 31.12 ± 2.97 ml) in diabetic patients (P<0.05). No significant volume change in the bilateral basal ganglia structures was found after insulin therapy for 1 year (P>0.05), and bilateral ventral diencephalon area showed an increased volume after the treatment (left, 3.26±0.68 ml;right, 3.20±0.78 ml) compared with the baseline (left, 2.96 ± 0.76 ml;right, 2.82 ± 0.90 ml) (P<0.05). Conclusion Type 2 diabetic patients have a decreased volume of the cortical and subcortical reward circuitry, and insulin therapy can reverse such changes and improve the damage of reward circuitry.
Keywords：type 2 diabetes mellitusbrainmagnetic resonance imaginreward circuitryentorhinal cortexnucleus accumbens
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 1265-1272 )