Study on correlation of disease status with D-dimmer level in acute leukemia patients
Abstract：Objective To investigate the correlation of plasma D-dimmerlevels with the status of acute leukemia and explore its clinical significance. Methods Five hundred bone marrow nucleated cells from patients with acute non-lymphoblastic leukemia (ANLL)and acute lymphoblastic leukemia (ALL) were isolated by routine microscopic counting. The plasma prothrombin time/international normalized ratio (PT/INR) and activated partial thromboplastin time (APTT) of the cells were measured by one-stage clotting method in a coagulation instrument. The content of D-dimmer was determined by latex agglutination assay. Results The total number of primary and naive cells was positively correlated with the PT/INR and D-dimmer level in both ANLL and ALL group,but the plasma PT/INR levels were largely within normal range with only a few exceptions. High abnormality rate of D-dimmer levels, however, was observed in paralleled with the total number primary and naive cells. Conclusion The variation of D-dimmer level can be the one of the index as to judge the disease status.
Machine-generated Keywords：
Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 40-41 )